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Case Report
A case of Primary Sclerosing Cholangitis with Ulcerative Colitis
Jung Sue Kim, Yon Ho Choe, Chong Jai Kim, Woo Sun Kim, In-One Kim, Jeong Kee Seo
Clin Exp Pediatr. 1996;39(10):1448-1454.   Published online October 15, 1996
An association between primary sclerosing cholangitis and ulcerative colitis is well known. But, primary sclerosing cholangitis with ulerative colitis has been rarely reported in children. The prevalence of primary sclerosing cholangitis among ulcerative colitis patiens is 3% in children. Primary sclerosing cholangitis is characterised by inflammation and fibrosis of the intrahepatic and extrahepatic bile ducts. The diagnosis of primary sclerosing cholangitis based on biochemical, histologic...
Original Article
Recent Changesin Prevalence of Hepatitis B Viral Markers in Preschool Children in Seoul,1995
Yon Ho Choe, Jeong Kee Seo, Jeong Hwan Yun, Hyo Seok Lee
Clin Exp Pediatr. 1996;39(9):1254-1259.   Published online September 15, 1996
Purpose : A nationwide hepatitis B vaccination publicity campaign and program was launched in 1988 in Korea. This survey was designed to evaluate the recent changes of the positive rates of hepatitis B surface antigen and antibody in sampled preschool children living in Seoul, 1995. Methods : Study population consisted of 218 preschool children aged 2 to 5 years. Most of them had been...
Case Report
A Case of Intestinal Neuronal Dysplasia
Se Young Kim, Yon Ho Choe, Jeong Kee Seo, In One Kim, Chong Jai Kim
Clin Exp Pediatr. 1996;39(8):1151-1157.   Published online August 15, 1996
Intestinal neuronal dysplasia(IND) is a disease characterized clinically by symptoms of intestinal obstruction and pathologically by hyperplasia of the submucosal and myenteric plexuses with formation of giant ganglia. Chronic intestinal pseudo-obstruction is a clinical diagnosis, composed of myopathic form and neuropathic form, and normal intestinal histology. Intestinal neuronal dysplasia is a neuropathic form of chronic intestinal pseudo-obstruction. The clinical presentation and the course of IND...
A Case Report of Autoimmune Hepatitis Associated with Choledochal Cyst and Pancreatitis
Kyung Ran Park, Sun Young Lee, Soon Young Kim, Hyoung Shim Chang, Nam Su Back, Chong Jai Kim, Joong Gon Kim, Jeong Kee Seo
Clin Exp Pediatr. 1996;39(8):1146-1150.   Published online August 15, 1996
Autoimmune hepatitis in children is a rare and severe inflammatory disease of unknown etiology, and progress to cirrohosis and liver failure, generally is responsive to immunosuppressive therapy. It is more prevalent in women than men, and characterized by the presence of circulating autoantibodies, a high serum globulin. Extrahepatic manifestations such as thyroiditis, ulcerative colitis, glomerulonephritis and autoimmune hemolytic anemia, are associated. We report, to our...
Clinical Lecture
Pediatric Endoscopy for the Diagnosis and Management of Gastrointestinal Diseases in Children
Jeong Kee Seo
Clin Exp Pediatr. 1996;39(4):461-474.   Published online April 15, 1996
Case Report
Four Cases of Congenital Esophageal Stenosis Due to Tracheobronchial Remnants
Gi Woong Sung, So Young Lee, Yeon Ho Choi, Kyoung Mo Kim, Jeong Kee Seo, In Won Kim, Kwi Won Park, Jong Je Kim
Clin Exp Pediatr. 1996;39(2):273-279.   Published online February 15, 1996
Esophageal stenosis due to tracheobronchial remnants is a rare cause of congenital esophageal stenosis. The cause is thought to be esophageal sequestration of tracheobronchial remnants during embryonic separation. Errors in diagnosis are common and high index of suspicion is required for accurate diagnosis, and resection of primary site with anastomosis is recommanded. Although a rare entity, esophageal stenosis due to...
A Case of Neonatal Cholestasis with Arthrogryposis Multiplex Congenita and Renal Tubular Insufficiency(ARC Syndrome)
Hi Soo Rhee, Soon Young Kim, Nam Sun Baik, Il Soo Ha, Jeong Kee Seo
Clin Exp Pediatr. 1996;39(1):126-130.   Published online January 15, 1996
We report a case of ARC syndrome with arthrogryposis multiplex congenita, renal tubular insufficiency and cholestasis. The Patient presented in the early neonatal period with micrognathia, low set ears, high arched palate, multiple joint contracture, conjugated hyperbilirubinemia and failure to thrive. He died at the age of 1 month despite medical therapy. Findings of renal tubular insufficiency included persistent renal...
Original Article
Evaluation of Severity of Childhood Pancreatitis with Multiple Factor Scoring Systems
Young In Choi, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(12):1653-1663.   Published online December 15, 1995
Purpose : Pancreatitis in children is not common but can be associated with severe morbidity rates. Early prognostic evaluation of acute pancreatitis assists in selecting those patients who should be closely monitored. We studied the clinical characteristics and prognostic factors in patients with acute pancreatitis. Methods : Twenty five children with pancreatitis were included ranging in age from 1.8 to 14.9...
Infantile Choledochal Cyst Presenting with Neonatal Cholestasis; Review of Anatomical and Clinical Aspect
Jae Won Jeong, Jeong Kee Seo, Kwi Won Park, In Won Kim
Clin Exp Pediatr. 1995;38(12):1629-1637.   Published online December 15, 1995
Purpose : Extrahepatic biliary atresia, neonatal hepatitis, Allagille syndrome are most common primary causes of the neonatal cholestasis. Infantile choledochal cyst is another primary disease presenting with neonatal cholestasis but its incidence is so low that it has been reported rarely. Choledochal cyst in infancy has been known to have clinically and anatomically different characteristics from ones after infancy. Thus...
Ischemic Hepatitis in Children after Cardiac Operation -Analysis of Clinical Characteristics, Risk Factors and Outcome-
Kyung Mo Kim, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(11):1540-1546.   Published online November 15, 1995
Purpose : We have experienced frequently the ischemic hepatitis after cardiac operations which shows rapid striking rise of transaminase. But the ischemic hepatitis in children after cardiac operation is not defined yet in Korea. We examined the clinical characteristics and analyzed the risk factors and outcome in 20 children who showed typical clinical course of ischemic hepatitis after cardiac operation. Methods...
Prevalence and Its Changes of Hepatitis B Viral Markers from 1988 to 1993 in Korean Children
Jae Geon Sim, Jeong Kee Seo, Seong Jae Suh
Clin Exp Pediatr. 1995;38(11):1535-1539.   Published online November 15, 1995
Purpose : Hepatitis B infection is prevalent in Korea and active immunization of Hepatitis B has been proceeded intensively during the last decade. This study was designed to evaluate the changes of the prevalence of hepatitis B surface antigen (HBsAg) and that of antibody (HBsAb) in Korean children from 1988 to 1993. We can estimate the prevalence and tendency of...
Case Report
A Case of Chronic Pancreatitis Complicated by Hemobilia
Sang Ook Nam, Jeong Kee Seo, Je Geun Chi, Kyung Mo Yeon
Clin Exp Pediatr. 1995;38(3):422-427.   Published online March 15, 1995
Hemobilia caused by pancreatic disease is very rare. The most common cause is a splenic artery pseudoaneurysm caused by acute and chronic inflammation of the pancreas. We experienced a case regarding as hemobilia as a complication of chronic relapsing pancreatitis in a 14 year-old boy. He was admitted with chief complaints of abdominal pain and hematemesis. Two years prior to admission,...
A Case of \Intractable Ulcerating Enterocolitis\" of Infant"
Ju Young Jeong, Jeong Kee Seo, Kwi Won Park, Je Geun Chi
Clin Exp Pediatr. 1995;38(2):264-270.   Published online February 15, 1995
Intractable ulcerating enterocolitis of infancy is uncommon, inhereditary disease characterized by ulcerating stomatitis, severe perianal disease, affecting the whole gastrointestinal tract, mainly colon with flask shaped large ulcer. It was first described by Sanderson et al in 5 cases of infant with intractable diarrhea having above clinical manifestation. It should be differentiated with Crohn's disease and Behcet's disease. We experienced a...
Longterm Follow Up of A Case of Eosinophilic Gastroenteritis
So Young Lee, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(1):104-109.   Published online January 15, 1995
Eosinophilic gastroenteritis(EG) is a rare disease characterised histologically by eosinophilic infiltration of the gut wall. The clinical features depend on which layer and location are involved. Patients may be divided into three clinical groups as predominantly mucosal, muscle layer, or subserosal disease based on the histological site of eosinophilic infiltration of the bowel wall, although there is lften considerable overlap....
Original Article
Uncooked Cornstarch Therapy in Type I Glycogen-Storage Diasese(GSD-I)
Seon Young Lee, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(1):36-46.   Published online January 15, 1995
Purpose : A few years ago it was shown that uncooked cornstarch feeding(UCS) could correct the biochemical abnormalities resulting from a deficiency of glucose-6-phosphatase in children with type ment. So far, little experience is available with UCS in Korea. We studied to compare the effects on biochemical control and growth of therapy with portacaval shunt and therapy with UCS. Methods : Enghteen...
Cricopharyngeal Incoordination in Infancy
Yong Joo Kim, Jeong Kee Seo
Clin Exp Pediatr. 1994;37(6):752-758.   Published online June 15, 1994
Cricopharyngeal incoordination of infancy is a rare disease, characterized by difficult swallowing soon after birth. Regurgitation, frequent choking and aspiration with deglutition, recurrent aspiration pneumonia, and to-and-fro movement of the contrast medium in the posterior pharynx on upper esophageal cineroentgenography. Clinical investigation was performed in the infants who were admitted due to difficult swallowing, reguritation, and recurrent pneumonia from March 1,...
Case Report
Candida Esophagitis in Infancy-A Report of 3 Cases
Ho Sung Kim, Youn Woo Kim, Jae Geon Sim, Beom Soo Park, Hoan Jong Lee, Joong Gon Kim, Jeong Kee Seo, Je Geun Chi
Clin Exp Pediatr. 1994;37(2):269-275.   Published online February 15, 1994
We experienced 3 cases of Candida esophagitis in infancy which were diagnosed by esophageal endoscopy, First case, 10 month-old boy with combined immune deficiency had suffered from oral thrush and poor feeding for more than 4 months. Esophageal endoscopy revealed multiple whitish creamy patches on the friable erythematous and necrotic mucosa of the esophagus, He was firstly treated with amphotericin-B...
Original Article
Choleithiasis in Childhood
Soon Young Kim, Jeong Kee Seo
Clin Exp Pediatr. 1994;37(1):70-77.   Published online January 15, 1994
Nineteen children found to have gallstones at Seoul National University of Children's Hospital form Jun. 1982 to Jun. 1992 wee reviewed. The results were as follows: 1) The mean age was 10 years, with 9 boys and 10 girls. Most of the cases (63%) were over 10 years of age. 2) Clinical manifestations were abdominal pain (14 cases), naused and/or vomiting (5 cases), fever...
Esophageal Varix in Children - Endoscopic Evaluation and Clinical characteristics-
Soon Young Kim, Jeong Kee Seo
Clin Exp Pediatr. 1993;36(12):1691-1700.   Published online December 15, 1993
Fifty five children with encoscopically proven esophageal varices form Jul. 1987 to Dec. 1992 were analyzed for endoscopic and clinical characteristics. The results were as follows : 1) According to etiological classification of portal hypertension in 55 cases, 35 cases showed intrahepatic causes (64%) and cases had extrahepatic causes (36%). The most common clinical manifestation on admission was hematemesis (42%) and abdominal mass...
A Genetic Linkage Study of Wilson Disease in Korean Families
Jong Won Kim, Sang In Kim, Jeong Kee Seo
Clin Exp Pediatr. 1993;36(11):1596-1612.   Published online November 15, 1993
Wilson disease gene (WND) locus is presumed to be located in chromosome 13q. There are studies on the clinical heterogeneities and variations between ethnic groups in Europe, North America, and the Middle East and it requites the study of another ethnic group, especially Asian population for the confirmation. This study was an analysis of restriction fragment length polymorphism of the Wilson's...
Chronic Idiopathic Intestinal pseudo-obstrucion Syndrome in Childhood
Jae Geon Sim, Jeong Kee Seo, Kui Won Park, Je Geun Chi
Clin Exp Pediatr. 1993;36(11):1583-1595.   Published online November 15, 1993
Chronic idiopathic intestinal pseudo-obstruction syndrome is a clinical condition induced by an impaired function of intestinal motility. Although its clinical symptoms are those of intestinal obstruction, mechanical obstruction of the intestine cannot be found by vigorous studies, even by operative exploration. We have experienced nine cases of chronic idiopathic intestinal pseudo-obstruction syndrome. It will help in diagnosis and treatment of the...
Case Report
A Case of Intestinal Lymphangiectasia
Yae Kyung Suh, Kyung Hee Park, Chul Ho Jang, Bum Soo Park, Jeong Kee Seo, Sung Hae Park, Je Geun Chi, Kyung Mo Yeon, Kwi Won Park
Clin Exp Pediatr. 1992;35(12):1737-1743.   Published online December 15, 1992
Intestinal lymphangiectasia is a primary or secondary disorder of the gastrointestinal tract, which is associated with lymphatic dysfuction and protein-losing enteropathy. It's clinical manifestations vary widely, but the main symptoms are abdominal distention, edema, abdominal pain and growth failure. We described a 15-yr-old boy, who suffered from above symptoms since third year of his age and diagnosed by duodenal endoscopy which...
Original Article
Gastrofiberscopic Findings and Helicobacter pylori Gastritis in Children with Recurrent Abdominal Pain
Jeong Kee Seo, Je Geun Chi, Eui Chong Kim
Clin Exp Pediatr. 1992;35(12):1646-1656.   Published online December 15, 1992
Gastrofiberscopic findings and the presence of Helicobacter pylori (H. pylori) were studied prospectively in children with recurrent abdominal pain (RAP). Endoscopic findings in 707 children with RAP revealed that 243 children (34.3%) showed abnormal findings including gastritis in 16.9%, duodenitis in 10.4%, esophagitis in 5.7%, duodenal ulcer in 5.7%, and gastric ulcer in 1.1% of children with RAP. Endoscopic biopsy of...
Case Report
A Case of Chronic Intestinal Pseudo-obstruction Syndrome
Hye Won Park, Chul Ho Chang, Bum Soo Park, Jeong Kee Seo, Sung Hye Park, Je Geun Chi, Kyung Mo Yeon, Kui Won Park
Clin Exp Pediatr. 1992;35(10):1427-1434.   Published online October 15, 1992
Chronic intestinal pseudo-obstruction is a clinical condition in which impaired intestinal propulsion causes recurrent symptoms of bowel obstruction in the absence of mechanical occlusion. In this paper a female neonate was presented with vomiting and abdominal distension in the first few days of life but passed normal meconium. Barium enema showed a microcolon and an abnormaly sited cecum. Malrotation of bowel...
Two Cases Antral Webs and One Case of Pyloric Web in Children
Young Mee Yoo, Hann Tchaha, Jeong Kee Seo, Kui Won Park, Woo Ki Kim, Kyung Mo Yeon
Clin Exp Pediatr. 1992;35(10):1411-1418.   Published online October 15, 1992
Antral or prepyloric mucosal diaphragms (webs) are composed of mucosa which enclose a membrane of submucosa and located at the antrum of the stomach at variable distances from the pylorus. They may be congential in origin or secondary to chronic peptic ulcer disease. Obstructive symptoms occur when diaphragmatic aperture is less than 1 centimeter. The diagnosis relies on the history,...
Three Cases of Post-transfusion Hepatitis C
Kyung Un No, Ho Seong Kim, Ji Won Choi, Dong Wook Kim, Cheol Ho Jang, Beom Su Park, Jeong Kee Seo, Gyeong Hoon Kang, Je Geun Chi
Clin Exp Pediatr. 1992;35(9):1255-1262.   Published online September 15, 1992
Hepatitis C virus has been known to be the main cause of post-transfusion non-A, non-B hepatitis. The authors experienced three cases of hepatitis C. All were associated with blood transfusions. They had no specific symptoms, and the levels of aminotransferases were markedly elevated and showed severe fluctuations in two cases. Anti-HCV tested two or three times were all positive, and...
Original Article
Cytomegalovirus Infection in Children: The Significance of CMV Specific IgM Antibody Test and Virus Isolation in the Urine
Dong Wook Kim, Hyun Kwack, Seong Hee Jang, I Seok Kang, Hoan Jong Lee, Jung-Hwan Choi, Jeong Kee Seo, Chong Ku Yun
Clin Exp Pediatr. 1992;35(7):890-901.   Published online July 15, 1992
The clinical pictures of 44 children with IgM antibody to CMV (cytomegalovirus) by ELISA(enzyme linked immunosorbent assay) were reviewed retrospectively, and the significance of serum CMV specific IgM antibody and virus isolation in the urine was analyzed. Age of the patients with IgM antibody to CMV ranged from 23 days to 8 years 7 months, and median age was 2 months....
Case Report
A Case of WDHA(Watery Diarrhea Hypokalemia Achiorhydria) Syndrome
Nam Seon Beck, Jun Jai Kim, Beom Soo Park, Jeong Kee Seo, Hyo Seop Ahn, Hyung Ro Moon, Je Geun Chi
Clin Exp Pediatr. 1992;35(4):575-580.   Published online April 15, 1992
VIP secreting tumors are rare in children but they produce a dramatic clinical picture, the most prominent feature of which is profuse, watery diarrhea and hypokalemia. A 5-year-old girl was brought to Seoul National University Children's Hospital for evaluation of profuse watery diarrhea. She presented with watery diarrhea, hypokalemia, and stunted growth, and had experienced these problems for four years...
Original Article
Endoscopic evaluation for gastrointestinal hemorrhage in childhood.
Cheol Ho Chang, Beom Soo Park, Jeong Kee Seo
Clin Exp Pediatr. 1991;34(4):515-524.   Published online April 30, 1991
The diagnosis and management of gastrointestinal tract hemorrhage in infants and children have been changed dramatically over the past decade. Although previous reviews of this subject have suggested that the cause of gastrointestinal tract bleeding may remain obscure in many patients, recent experience indicates that this is now uncommon. This advance is largely a result of the widespread and now routine application of fiberoptic...
A case of Caroli's disease.
Seong Hee Jung, Cheol Ho Chang, Han Tchah, Jeong Kee Seo, Kwi Won Park, In One Kim, Kyung Mo Yeon, Je Geun Chi
Clin Exp Pediatr. 1991;34(2):261-266.   Published online February 28, 1991
Caroli’s disease was first described by Caroli in 1958 and characterized by segmental cystic dilatation of the intrahepatic bile ducts. There is stasis of bile with stone formation in the dilatated ducts, giving rise to frequent attacks of pain and cholangitis. In the past, diagnosis of the Caroli’s disease is rarely established prior to operation and subsequent cholangiography. Recently, with ultrasonography, computerized tomography, radioisotope...
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